Searchable abstracts of presentations at key conferences in endocrinology

ea0009p50 | Growth and development | BES2005

Nebivolol inhibits spontaneous and oxytocin-induced contractions in the rat uterus

Kavak B , Simsek M , Kutlu S , Ozcan M , Kumru S , Yilmaz B , Kelestimur H

Nebivolol is a recently developed beta(1)-selective adrenergic receptor antagonist with proposed nitric oxide mediated vasodilating properties. Effect of nebivolol on vascular smooth muscle has been attributed to estrogen receptor-mediated vascular responsiveness. Although it is known that nitric oxide has relaxing effect on myometrium, there is no report whether nebivolol application affect myometrial contractility. Therefore, we have investigated the effect of nebivolol on r...